Rhodiola Rosca Extract
Salidroside
CAS: 10338-51-9;97404-52-9
Molecular Formula: C14H20O7
Rhodiola Rosca Extract - Names and Identifiers
| Name | Salidroside |
| Synonyms | rhodosin Salidroside Rhodioloside SALIDROSIDE(P) RhodiolaExtract Rhodiola Extract Q439 Salidroside TWEEN 20 EXTRA PURE Salidroside Extract. Rhodiola Rosca Extract Rhodiola rosea extract RhodiolaCrenulataExtract Smilax aristolochiaefolia, ext. Salidroside, froM Herba rhodiolae glucopyranoside,p-hydroxyphenethyl 2-(4-hydroxyphenyl)ethyl beta-D-glucopyranoside 2-(4-HYDROXYPHENYL)ETHYL-BETA-D-GLUCOPYRANOSIDE beta-d-glucopyranoside,2-(4-hydroxyphenyl)ethyl 2-(4-Hydroxyphenyl)ethyl betta-D-glucopyranoside |
| CAS | 10338-51-9 97404-52-9 |
| EINECS | 695-621-2 |
| InChI | InChI=1/C14H20O7/c15-7-10-11(17)12(18)13(19)14(21-10)20-6-5-8-1-3-9(16)4-2-8/h1-4,10-19H,5-7H2/t10-,11-,12+,13-,14-/m1/s1 |
| InChIKey | ILRCGYURZSFMEG-RKQHYHRCSA-N |
Rhodiola Rosca Extract - Physico-chemical Properties
| Molecular Formula | C14H20O7 |
| Molar Mass | 300.3 |
| Density | 1.46±0.1 g/cm3(Predicted) |
| Melting Point | 159～160℃ |
| Boling Point | 549.5±50.0 °C(Predicted) |
| Specific Rotation(α) | (c, 1.26 in H2O)-32.1 |
| Flash Point | 286.2°C |
| Solubility | Easily soluble in hot water, soluble in methanol, ethanol and ethyl acetate, slightly soluble in ether, insoluble in benzene and petroleum ether, acetone, etc. |
| Vapor Presure | 6.54E-13mmHg at 25°C |
| Appearance | Colorless transparent needle crystal |
| Color | Off-White |
| pKa | 9.98±0.15(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.628 |
| MDL | MFCD00210553 |
| Physical and Chemical Properties | It is derived from the dried roots and rhizomes of Rhodiola crenulata(Hook.f.et.Thoms.)H.Ohba. |
Rhodiola Rosca Extract - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36 - Irritating to the eyes |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| RTECS | LZ5901900 |
| HS Code | 29389090 |
Rhodiola Rosca Extract - Reference
| Reference Show more | 1. Ye Miaoyong, Zhao Fan, Ma Ke, etc Effect of H2O2 on connexin 43 protein expression in rat penile cavernous smooth muscle cells and intervention of salidroside [J] Chinese Journal of Andrology 2019 (8). 2. Li Wangying, Wang Xingfang, Li Jun, et al Comparison of chemical constituents extracted from Rhodiola tangutica with different solvents and determination of salidroside content [J] Journal of Gansu Agricultural University 2014 (5): 63-69. 3. Liu Shumin, Zhang Shuai, Zhang Ning, et al Discovery of potential target network of Acanthopanax senticosus to assist the effect of active components [J] Pharmacology and Clinic of Traditional Chinese Medicine 2017 (05): 127-132. 4. Ji Xin, Liu Xiaoqian, Li Chun, et al Study on the processing change rule of main components in Ligustrum lucidum based on UPLC technology and discussion on the characteristic quality standard of Ligustrum lucidum wine [J] Chinese Journal of Traditional Chinese Medicine, 2018, 43 (24): 128-134. 5. Xu Feng, Yang Ye, Shu Qiu'e, etc HPLC fingerprint of Caulis spatholobi [J] Chinese Journal of Experimental Formulas, 2013. 6. Xu Feng, Yang Ye, Shu Qiu'e, et al Analysis of UPLC fingerprint of Caulis spatholobi [J] Chinese Journal of Experimental Formulas, 2013. 7. Ji Xin, Liu Xiaoqian, Xiao Suping, et al Qualitative and quantitative studies on non triterpenoids in Ligustrum lucidum [J] Chinese Journal of Traditional Chinese Medicine, 2019, 044 (008): 1615-1622. 8. Li Jing, Zhu Na, Zheng Fei, et al Extraction Process of Red Ginseng Rhodiola Mixture and Its Anti fatigue Effect [J] Food Industry Science and Technology, 2019, 040 (016): 181-185191. 9. Qin Xueqin, Chen Yue, Lei Shangfang, Chen Desen. Experimental study on salidroside in preventing and treating fatigue syndrome after liver transplantation in rabbits [J]. Hainan Medical Journal, 2017, 28 (12): 1893-1896. 10. Chen Honghong, Mo Shurong, Wu You Synergistic inhibitory effect of salidroside and astragalus injection on the proliferation of human hepatoma HepG2 cells [J] Genomics and Applied Biology, 2016, 35 (009): 2241-2245. Ma Ying, Liu Jing, Pan Tao. Study on the protective effect and mechanism of salidroside on H9c2 myocardial cells injured by stress and high glucose [J]. Journal of Nanjing University of Traditional Chinese Medicine, 2019, 35 (04): 442-447. 14. Lu Hongmei, Guo Yunhui, Zhao Yunbo. Study on the effect and mechanism of salidroside on human hepatoma cell HepG-2 [J]. Contemporary Medicine, 2013, 19 (26): 29-30. 15. Wei Lilan, Mo Shurong. In vitro experimental study of salidroside on human gastric cancer cell SGC-7901 [J]. Journal of Shandong University (Medical Edition), 2015,53 (12): 12-15+32. 16. Gao Jianfeng, Zhao Shijie, Zhou Li, etc Effects of salidroside on HIF-1 of chicken embryo lung microvascular endothelial cells cultured under hypoxia α Effect of expression level [J] Chinese Journal of Veterinary Medicine, 2016, 36 (10): 1733-1736. 17. Yan Junfeng, Zhao Jianfeng, Zhang Gaoyue, Huang Xiaojun, Chen Gang, Lu Bodong Effect of salidroside on the expression of connexin 43 in rat penile cavernous smooth muscle cells under hypoxia [J]. Chinese Journal of Andrology, 2016,22 (08): 725-729. 18. Gao Lili, Wu Chenghan, Cai Weiwu The effect of salidroside on neural function after intracerebral hemorrhage in rats [J] China Health Standards Management, 2019, 10 (02): 118-121. 19. Gao Jin, Luo Wei, Wang Qin, et al Effects of salidroside on proliferation and IMP3 expression of cervical carcinoma Siha cells [J] Chongqing Medical Journal, 2016, 45 (027): 3849-3851. 20. Zhang Lixia, Wang Tao, Niu Caiqin. The effect and significance of salidroside on Eag1 expression in mouse cervical cancer xenografts [J]. Chongqing Medical Journal, 2017, 46 (25): 3470-3472+3476. 21. Huang Yuzhe, Liu Lixia, Qiu Yutong, etc Study on the protective mechanism of salidroside on rats with chronic renal failure [J] Journal of Hebei Medical University, 2019 (8): 882-885. 22. Zhang Lichao, Wang Chenyu, Cao Huifang, et al The protective effect of salidroside on liver in rats with obstructive jaundice and its mechanism [J] Shandong Medical Journal, 2015, 000 (046): 32-33. 23. Zhou Liping, Li Xin, Tang Chaoyuan, Ge Tingting, Lin Deju, Hu Chuanqin, Yu Qin. Preliminary study on the effect of salidroside on the proliferation and antioxidant capacity of mesenchymal stem cells after hypoxia injury [J]. Journal of Zhejiang University of Traditional Chinese Medicine, 2016,40 (09): 643-647. 24. Zhang Dan, Cao Lihua, Wang Zhenshan, Xu Mingtao, Li Menglu, Feng Haoshen, Cai Xu, Yu Na, Health. Study on the effect of salidroside on skeletal muscle function of rats with chronic obstructive pulmonary disease induced by cigarette smoke [J]. Journal of Dalian Medical University, 2019, 41 (03): 199-204+209. 25. Liu Lian, Cui Shuyan, Wang Chenxue, et al. Study on the effect of salidroside combined with doxorubicin on HepG2 liver cancer in nude mice [J] Journal of Modern Integrated Chinese and Western Medicine, 2019 (21). 26. Zhu Lin, Wang Yanjun, Yu Tianhong, Luo Guanghua, Wei Jiang, Yu Yang, Jia Fang, Sun Jianhui Salidroside reduces the injury of human umbilical vein endothelial cells induced by high homocysteine by inhibiting endoplasmic reticulum stress [J]. Chinese Journal of Atherosclerosis, 2015,23 (01): 5-10. 27. Huang Feifei, Li Yaozhe, Zhang Ting, Wang Liangxing, Huang Xiaoying. Salidroside prevents hypoxic pulmonary hypertension in rats by inhibiting oxidative stress [J]. Chinese Journal of Pathophysiology, 2018,34 (03): 500-506. 28. Wang Qing, Wang Yingzi, Li Youlin, et al Study on HPLC fingerprint of Honghefang preparation [J] Journal of Beijing University of Traditional Chinese Medicine, 2016, 39 (001): 40-45. 29. Yu Tianhong, Zhu Lin, Zhao Rong, Wang Yanjun, Sun Jianhui, Jia Fang The role of adenylate protein kinase activation in salidroside inhibiting homocysteine induced endoplasmic reticulum stress in human umbilical vein endothelial cells [J]. Chinese Journal of Traditional Chinese Medicine, 2017,35 (10): 2558-2562. 30. Liu Wenjing, Cao Yan, Song Qingqing, et al Qualitative analysis of chemical constituents of flowers and lignified stems of Cistanche deserticola [J] Chinese Journal of Traditional Chinese Medicine, 2018, 43 (018): 3708-3714. 31. Li Yiyao, Jian Yuxuan, Dou Chun, et al Study on the protective effect of salidroside on furan induced liver injury in mice [J] Processing of Agricultural Products (the first half of the month), 2019 (15). 32. Song Qingqing, Zhang Ke, Li Ting, Guan Pengwei, Gong Xingcheng, Xu Xia, Li Jun, Tu Pengfei, Song Yuelin. Simultaneous determination of multi component content of Cistanche deserticola by reverse phase hydrophilic interaction chromatography customized multi reaction monitoring [J]. Analytical Chemistry, 2020,48 (11): 1573-1593. 33. Ma Ling, Wang Nan, Du Li. Effects of salidroside on myocardial autophagy in rats under hypoxic environment [J]. Chinese Journal of Clinical Pharmacology, 2020,36 (21): 3450-3 453 34. Yibo Feng, Xiaojuan Zhao, Fang Lv, Jinqiu Zhang, Bihua Deng, Yanhong Zhao, Yuanliang Hu, Deyun Wang, Jiaguo Liu, Yu Lu, Ruonan Bo, Zhenguang Liu, "Optimization on Preparation Conditions of Salidroside Liposome and Its Immunological Activity on PCV-2 in Mic 35. Yuan Yuan, Xuan Wu, Xu Zhang, Yilin Hong, Haiyang Yan,Ameliorative effect of salidroside from Rhodiola Rosea L. on the gut microbiota subject to furan-induced liver injury in a mouse model,Food and Chemical Toxicology,Volume 125,2019,Pages 333-340,IS 36. Hu, Fangli, Xiaoyan Liao, and Zilin Chen. "Determination of three phenylethanoid glycosides in Osmanthus fragrans fruits by high‐performance liquid chromatography with fluorescence detection." Journal of separation science 41.21 (2018): 3995-4000. https:// 37. Nan, Xingmei, et al. "Bioactive fraction of Rhodiola algida against chronic hypoxia-induced pulmonary arterial hypertension and its anti-proliferation mechanism in rats." Journal of ethnopharmacology 216 (2018): 175-183.https://doi.org/10.1016/j.jep.2018.0 38. [IF=6.06] Jiahong Han et al."Compatibility effects of ginseng and Ligustrum lucidum Ait herb pair on hematopoietic recovery in mice with cyclophosphamide-induced myelosuppression and its material basis."J Ginseng Res. 2020 Mar;44:291 39. [IF=6.023] Yuan Yuan et al."Ameliorative effect of salidroside from Rhodiola Rosea L. on the gut microbiota subject to furan-induced liver injury in a mouse model."Food Chem Toxicol. 2019 Mar;125:333 40. [IF=5.279] Yirong Jiang et al."Phenylethanoid Glycoside Profiles and Antioxidant Activities of Osmanthus fragrans Lour. Flowers by UPLC/PDA/MS and Simulated Digestion Model."J Agr Food Chem. 2016;64(12):2459–2466 41. [IF=5.279] Xiaoyan Liao et al."Identification and Quantitation of the Bioactive Components in Osmanthus fragrans Fruits by HPLC-ESI-MS/MS."J Agr Food Chem. 2018;66(1):359–367 42. [IF=4.556] Maiquan Li et al."Neuroprotective Effects of Four Phenylethanoid Glycosides on H2O2-Induced Apoptosis on PC12 Cells via the Nrf2/ARE Pathway."Int J Mol Sci. 2018 Apr;19(4):1135 43. [IF=3.046] Liwei Dong et al."Echinacoside induces apoptotic cancer cell death by inhibiting the nucleotide pool sanitizing enzyme MTH1."Oncotargets Ther. 2015; 8: 3649–3664 44. [IF=2.629] Zhang Bu-Chun et al."Salidroside Decreases Atherosclerotic Plaque Formation in Low-Density Lipoprotein Receptor-Deficient Mice."Evid-Based Compl Alt. 2012;2012:607508 45. [IF=2.371] Wang Xu-Lei et al."Salidroside Improves Doxorubicin-induced Cardiac Dysfunction by Suppression of Excessive Oxidative Stress and Cardiomyocyte Apoptosis."J Cardiovasc Pharm. 2013 Dec;62(6):512-523 46. [IF=2.1] Lin Sun et al."Salidroside slows the progression of EA.hy926 cell senescence by regulating the cell cycle in an atherosclerosis model."Mol Med Rep. 2018 Jan;17(1):257-263 47. [IF=1.851] Xujiao Huang et al."Salidroside protects PC12 cells from Aβ1‑40‑induced cytotoxicity by regulating the nicotinamide phosphoribosyltransferase signaling pathway."Mol Med Rep. 2017 Sep;16(3):2700-2706 48. [IF=1.297] Shi Kai et al."Salidroside protects retinal endothelial cells against hydrogen peroxide-induced injury via modulating oxidative status and apoptosis."Biosci Biotech Bioch. 2015 Sep;79(9):1406-1413 49. [IF=9.783] Huiping Bi et al."Biosynthesis of a rosavin natural product in Escherichia coli by glycosyltransferase rational design and artificial pathway construction."Metab Eng. 2022 Jan;69:15 50. [IF=5.076] Zhang Zepeng et al."Shen-Hong-Tong-Luo Formula Attenuates Macrophage Inflammation and Lipid Accumulation through the Activation of the PPAR-γ/LXR-α/ABCA1 Pathway."Oxid Med Cell Longev. 2020;2020:3426925 51. [IF=4.679] Yuan Yuan et al."Salidroside ameliorates liver metabonomics in relation to modified gut-liver FXR signaling in furan-induced mice."Food Chem Toxicol. 2020 Jun;140:111311 52. [IF=4.237] Xiaoping Chen et al."Salidroside ameliorated hypoxia‐induced tumorigenesis of BxPC‐3 cells via downregulating hypoxia‐inducible factor (HIF)‐1α and LOXL2."J Cell Biochem. 2020 Jan;121(1):165-173 53. [IF=4.221] Yuan Yuan et al."Salidroside alleviates liver inflammation in furan-induced mice by regulating oxidative stress and endoplasmic reticulum stress."Toxicology. 2021 Sep;461:152905 54. [IF=4.142] Wang Chenxi et al."Systematic quality evaluation of Peiyuan Tongnao capsule by offline two-dimensional liquid chromatography/quadrupole-Orbitrap mass spectrometry and adjusted parallel reaction monitoring of quality markers."Anal Bioanal Chem. 2019 Nov;4 55. [IF=3.373] Tian Tian et al."Non-targeted screening of pyranosides in Rhodiola crenulata using an all ion fragmentation-exact neutral loss strategy combined with liquid chromatography-quadrupole time-of-flight mass spectrometry."Phytochem Analysis. 2021 Nov;32(6):103 56. [IF=2.942] Zhang Dan et al."Salidroside mitigates skeletal muscle atrophy in rats with cigarette smoke-induced COPD by up-regulating myogenin and down-regulating myostatin expression."Bioscience Rep. 2019 Nov;39(11):BSR20190440 57. [IF=2.896] Zhang Ke et al."Online energy-resolved MS boosts the potential of LC-MS towards metabolite characterization of salidroside and tyrosol."Anal Methods-Uk. 2020 Nov;12(42):5120-5127 58. [IF=2.749] Xue Luan et al."Salidroside Mitigates Airway Inflammation in Asthmatic Mice via the AMPK/Akt/GSK3β Signaling Pathway."Int Arch Allergy Imm. ;:1-11 59. [IF=2.611] Zhou Liping et al."Salidroside-pretreated mesenchymal stem cells contribute to neuroprotection in cerebral ischemic injury in vitro and in vivo."J Mol Histol. 2021 Dec;52(6):1145-1154 60. [IF=1.902] Chenxi Wang et al."Multiple component-pharmacokinetic studies on 10 bioactive constituents of Peiyuan Tongnao capsule using parallel reaction monitoring mode."Biomed Chromatogr. 2021 Oct;35(10):e5153 61. [IF=1.902] Danjie Zhang et al."Analysis of chemical variations between raw and wine-processed Ligustri Lucidi Fructus by ultra-high-performance liquid chromatography–Q-Exactive Orbitrap/MS combined with multivariate statistical analysis approach."Biomed Chromatogr. 62. [IF=1.448] Ruoshui Li et al."Salidroside prevents tumor necrosis factor‑α‑induced vascular inflammation by blocking mitogen‑activated protein kinase and NF‑κB signaling activation."Exp Ther Med. 2019 Nov;18(5):4137-4143 63. [IF=3.645] Danjie Zhang et al.Systematic characterization of the absorbed components of Ligustri Lucidi Fructus and their metabolic pathways in rat plasma by ultra-high-performance liquid chromatography-Q-Exactive Orbitrap tandem mass spectrometry combined with netw 64. [IF=3.307] Yue-Jun Hao et al."Selection of initial culture medium in fed-batch bioreactor culture of Rhodiola sachalinensis cells."J Biotechnol. 2022 Feb;346:15 65. [IF=1.134] Ting-Ting ZHANG et al."Construction of ERGO film modified electrode and its combination with HPLC in determination of five active components in Osmanthus fragrans fruits."CHINESE JOURNAL OF ANALYTICAL CHEMISTRY. 2022 Jul;50:100109 66. [IF=4.575] Shu Xing-Mei et al."Salidroside alleviates cadmium-induced toxicity in mice by restoring the notch/HES-1 and RIP1-driven inflammatory signaling axis."INFLAMMATION RESEARCH. 2022 May;:1-12 |
Rhodiola Rosca Extract - Reference Information
| Plant source: | Rhodiola rosea |
| properties | light brown red to white crystalline powder; The air is fragrant and bitter. |
| use | has the functions of improving immunity, strengthening physique, improving human hematopoietic function, anti-hypoxia, anti-aging, anti-tumor, anti-fatigue, lowering blood sugar, anti-virus, anti-radiation, protecting cardiovascular and cerebrovascular diseases and preventing altitude sickness. used for content determination/identification/pharmacological experiment, etc. Pharmacological effects: enhance immunity, eliminate depression and protect cardiovascular system. Antibacterial effect, protect cardiovascular function, effective antioxidants, anti-cancer activity, improve memory, anti-radiation effect |
| plant extract | salidroside is a compound extracted from the dried root and rhizome or dried whole plant of the crassulaceae plant Rhodiola. It has the effects of preventing tumors, enhancing immune function, delaying aging, resisting fatigue, resisting hypoxia, preventing radiation, regulating central nerves in two directions, repairing and protecting the body, etc. It is usually used as a treatment for chronic patients and frail and susceptible patients. It is clinically used to treat neurasthenia and neurosis, improve attention, memory, high altitude polycythemia, and hypertension; as a nerve stimulant, it is used to improve intellectual ability and improve autonomic nerve-vascular dystonia. Muscle weakness, etc.; used for diseases with increased free radicals, such as tumors, radiation damage, emphysema, senile cataracts, etc.; also used as a strong agent for impotence, etc.; salidroside preparations are also used in sports medicine and aerospace medicine, used for health protection of workers under various special environmental conditions. Rhodiola has the function of adapting to the original and two-way adjustment. Inhibitory changes in monoamine transmitters, cyclic adenosine monophosphate in spleen and thymus, lymphocyte transformation rate, serum hemolysin, etc. in the brain of mice irradiated by microwave can restore it to normal. After injection of salidroside, it can enhance the thyroid function and adrenal function of rabbits, and can stimulate the endocrine function of mouse eggs. Improve concentration and memory. Increase the level of β-indoxol in plasma and prevent changes in stress hormones. |
| Rhodiola rosea | Rhodiola rosea is the dry root and rhizome of the Crassulaceae plant Rhodiola rosea. There are nearly 100 species of Rhodiola in the world, mainly distributed in the Himalayas, northwestern Asia and North America. There are more than 80 kinds in my country, mostly distributed in the southwest, northwest, north and northeast regions. The main producing areas are Jilin, Hebei, Qinghai, Xinjiang, Sichuan, Yunnan, Guizhou, Tibet and other provinces. Rhodiola rosea is an important source of medicinal plants to develop new anti-fatigue, anti-hypoxia and anti-aging. Rhodiola rosea extract is a product extracted from dried rhizomes such as Rhodiola Rhodiola rosea L., and the commercial extract is usually standardized to contain salidroside 4%. Figure 1 is a diagram of Rhodiola plants Modern medical research has proved that the treasure of Rhodiola rosea contains rhodiola, salidroside, salidroside tyrosol, rhodiola lactone, as well as 35 kinds of trace elements, 18 kinds of amino acids, vitamin A, vitamin D, vitamin E and SOD. the content of salidroside in different species of Rhodiola plants varies greatly. Wang Xiaoqin determined the content of salidroside in 6 species of Rhodiola plants produced in Qinghai by HPLC (see Table 6-5). fig. 2 shows the content table of salidroside in 6 rhodiola plants produced in Qinghai |
| pharmacological action | 1. anti-fatigue effect: oral administration of Rhodiola angustifolia prolongs the climbing time, swimming time and load swimming time of mice. It can shorten the time required for recovery after fatigue, increase the levels of enzymes, RNA and proteins, and make the muscles recover as soon as possible after fatigue. 2. Effect on central nervous media: Rhodiola rosea can normalize the content of serotonin in mice under swimming conditions, that is, the content of central nervous media from normal sand dunes has been corrected or reached normal levels. Injection of salidroside (30-300mg/kg) in mice reduced the level of serotonin. 3. Anti-hypoxia effect: Oral administration of extracts from Rhodiola, Rhodiola angustifolia, and Crimson Rhodiola can make experimental animals show obvious antagonism to various hypoxia patterns, and its effect is stronger than ginseng and Acanthopanax. 4. Anti-aging effect: Rhodiola rosea alcohol extract can improve the activity of SOD in red blood cells and liver of rats, and has a tendency to increase the activity of SOD in myocardium. Red wild flax fly drinking rhodiola extract, can significantly prolong life, life extension rate is better than ginseng. Rhodiaxin can promote the proliferation of 2BS cells and reduce mortality, inhibit lipid peroxide and enhance the activity of serum superoxide dismutase in rat cells. 5. Anti-tumor: Rhodiola does have a certain inhibitory effect on S180 cells. In the range of non-toxic side dose, this effect increases with the increase of concentration. Continuous oral administration of Rhodiola rosea extract can reduce the degree of carcinogenic damage of erythromycin to the small intestinal wall of mice and improve the anti-cancer ability of the body. 6. Detoxification: Salidroside has the effect of antagonizing strychnine poisoning, and can increase the survival rate of mice after strychnine poisoning by 50%; it also has the effect of antagonizing coryneform toxins and can resist tetanus Various bacterial toxins such as wind increase the survival time or survival rate of mice taking strong poisons, sodium cyanide, and sodium nitrite. |
| quantitative analysis of natural drug rhodiola composition | [test article] crassulaceae plant rhodiola (rhodiola angustifolia) Rhodiola kirilowii(Regel) Regel and the same genus alpine rhodiola R. Sachalinensis A. Bor. Dry roots and rhizomes or dry whole grass. (1) chromatographic conditions chromatographic column: μ-Bondapak ODS column (3.9mm × 30cm,10 μm); Mobile phase: methanol-water (2:8); Flow rate: 1.0 ml/min; Column temperature: room temperature; Detection wavelength: 276nm. (2) preparation of reference substance solution: accurately weigh appropriate amount of salidroside reference substance, add methanol to prepare a solution containing 0.04mg per milliliter as the reference substance solution. (3) preparation of sample solution: accurately weigh 1g of crude drug powder, place it in a Soxhlet extractor, add 30ml of methanol, extract for 2 hours, filter the extract, place the filtrate in a 50ml volumetric flask, and add methanol to dilute to scale. As a sample solution. (4) determination take 10 μl of sample and 10 μl of reference solution for sample injection and analysis to obtain. (5) chromatogram fig. 3 is a high performance liquid chromatogram of rhodiola rosea (I. Rhodiola rosea; II. Rhodiola extract 1. salidroside) (6) determination results fig. 4 is the content chart of salidroside in the sample |
| extraction and separation method of salidroside | the roots and rhizomes of rhodiola rosea are crushed into coarse powder, refluxed with 70% ethanol for extraction, the extract is separated, and ethanol is recovered under reduced pressure. the obtained concentrated solution is stirred evenly with the same amount of water, let stand, filtered, and treated repeatedly for 3 times. the filtrate is concentrated under reduced pressure and extracted with petroleum ether, chloroform, ethyl acetate and n-butanol in turn, ethyl acetate and n-butanol were partially recovered from solvents to obtain crude tyrosol and crude salidroside. |
| preparation method | obtained by condensation of o-methylbenzaldehyde and acetaldehyde under alkaline conditions |
Last Update：2024-04-09 20:49:11
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